Hemp Oil For Anxiety

Hemp Oil For Anxiety

Hemp Oil For AnxietyThere is exciting new research on how hemp oil helps with anxiety. Clinical studies are leading the way that certain cannabinoids in hemp oil could not only help with anxiety, but could help with depression as well.

Far too often CBD gets all the credit, and as you will see further down, CBC may be just as important in any treatment. In many of the studies, researchers noted that primary cannabinoids like CBD and CBC work more effectively when the other 100 cannabinoids, terpenes and flavonoids are present.

The studies performed so far are showing that cannabinoids can influence anxiety, depression, panic attacks, PTSD and more.

The best way to understand the developments is to dig into the research, and discuss the findings. Below we will highlight the most important studies that shed light on how hemp oil can help with these conditions and disorders.

How Hemp Oil Can Treat Anxiety

Social anxiety disease (SAD) can be a crippling condition, from the fear of public speaking, to the fear of interacting with others, to the highly dreaded panic attacks.

Within hemp oil, there are over 100 different cannabinoids that interact with our brain and nerves, not to mention our lymphatic system and white blood cells. The discussion tends to center upon CBD when talking about anxiety, but in reality there are at least two cannabinoids that deserve attention for anxiety treatment.

We will try to shine a light on these two top cannabinoid performers that help with anxiety, panic attacks, depression and PTSD.

CBD Hemp Oil For Anxiety

CBD, or Cannabidiol, is a naturally occurring cannabinoid found in hemp plants and hemp oil. CBD is found in abundance in the flowers and leaves of the plant.

Of all the over 100 cannabinoids found in hemp, CBD has to be the most studied of all the non-psychoactive cannabinoids.

Below are several important studies detailing successes with CBD in the treatment of anxiety:

Hemp Oil And Social AnxietySocial Anxiety Disorder – In September, 2010, Dr. Jose Crippa[1] ran a double-blind study which showed that “CBD (cannabidiol) markedly reduced symptoms of social anxiety disorder”. Testing revealed that CBD changed the blood flow to areas of the brain associated with anxiety.

Public Speaking – In May, 2011, Dr. Bergamaschi[2] ran a double-blind study on patients who performed public speaking, and measured vitals after being given CBD. It was found that the CBD “significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech.”

Depression – In September, 2011, Dr. Haj-Dahmane[3] found that CBD plays a significant role in modulating the serotonin system by influencing endocannabinoid receptors. This means that cannabinoids such as CBD may play an important role in regulating depression, as evidenced by the study’s findings which stated “Ample evidence from behavioral studies also suggests that eCBs are important regulators of stress responses and a deficit in eCB signaling contributes to stress-related disorders such as anxiety and depression”.

General Anxiety – In April 2012, Dr. Tambaro[4] found that certain cannabinoids like CBD do help with anxiety. What was interesting about this study was that Dr. Tambaro suggests that “administration of low doses” of CBD were effective, while “excessive doses may aggravate anxiety”.

Social Anxiety, Panic, OCD, PTSD Disorders – In October, 2015, Dr. Blessing[5] studied all of the available preclinical, human experimental, clinical and epidemiological studies on CBD as it related to anxiety. Dr. Blessing found that “evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive–compulsive disorder, and post-traumatic stress disorder”. The study also noted that there is a lack of information on proper dosing.

PTSD, Anxiety, Sleeplessness – In October, 2016, Dr. Shannon[6] treated a 10 year old girl with PTSD accompanied by generalized anxiety disorder and sleeplessness. As noted in the study, “The main finding from this case study is that CBD oil can be an effective compound to reduce anxiety and insomnia secondary to PTSD”.

PTSD – In July, 2018, Dr. Bitencourt and Dr. Takahashi[7] were able to demonstrate that CBD can help with the extinction of aversive memories causing PTSD. Maybe of equal importance was the finding that “CBD also shows an action profile with fewer side effects than the pharmacological therapy currently used to treat this type of disorder”.

CBC Hemp Oil For Anxiety

CBC, or Cannabichromene, is a naturally occurring cannabinoid found in hemp plants and hemp oil.

CBC has been found to be an effective sleep aid, but has also been found to have an important role with the endocannabinoid system (ECS).

Below are two studies which reinforce the importance of CBC with depression and brain health:

Depression – In June, 2010, Dr. El-Alfy[8] found that CBC showed “significant anti-depressant like effects”. The study further went on to note that Delta(9)THC, CBC and “other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis”.

Brain Health – In November, 2013, Dr. Shinjyo[9] found that CBC had a positive effect on “adult neural stem progenitor cells (NSPCs), which are an essential component of brain function in health”. The conclusion was that CBC increased the viability and health of adult stem cells in the brain.

Hemp Oil, Anxiety and Panic Attacks

Hemp Oil and Panic AttacksThe studies noted above indicate a very strong likelihood that CBD may play a role in many psychological conditions, especially anxiety and panic attacks.

These studies show that CBD appears to possess great promise for minimizing the anxiety associated with giving speeches, as well as generalized social anxiety disorder (SAD).

CBD has shown that by working with CB1 and CB2 receptors in our neurological system, changes have occurred in blood flow in areas of the brain that control anxiety.

The impact of the neurological and chemical effects of CBD and similar cannabinoids are not fully understood yet, but significant progress has been made showing the link between our endocannabinoid system and our serotonin system. This is extremely important as the serotonin system regulates mood and social behavior.

The 2011 study by Dr. Crippa revealed that CBD directly activates the 5-HT1A serotonin receptor, thereby creating an anti-anxiety effect.

Hemp Oil and Depression

Hemp Oil and DepressionMore studies are forthcoming, but as of right now, CBD (cannabidiol) and CBC (cannabichromene) appear to be the best cannabinoids for treating depression.

The 2010 study by Dr. El-Alfy showed that CBC demonstrated “significant anti-depressant like effects”.

The 2011 study by Dr. Haj-Dahmane put a bright spotlight on how our endocannabinoid system (ECB) interacts with our serotonin system.

The reason that the study by Dr. Haj-Dahmane is so important is because it highlights the fact that if you can affect the behavior of CB1 and CB2 receptors in our ECB system (which is exactly what CBD does) – then you can affect the serotonin levels – which is key to regulating depression.

Hemp Oil and PTSD

Hemp Oil and PTSDAs of this writing, CBD appears to be the optimal cannabinoid used to treat PTSD. We will also be paying close attention to CBC on this issue as there may also be promise with that cannabinoid as well.

The 2015 study by Dr. Blessing stated that “evidence strongly supports CBD as a treatment for …post-traumatic stress disorder”.

The 2016 study by Dr. Shannon found that “CBD oil can be an effective compound to reduce anxiety and insomnia secondary to PTSD”.

The 2018 study by Dr. Bitencourt and Dr, Takahashi demonstrated that aversive memories could be eliminated through CBD treatment. They also found that “CBD also shows an action profile with fewer side effects than the pharmacological therapy currently used to treat this type of disorder”.

With the additional research being performed on CBC to understand its affect on treating anxiety, do not be surprised if they find additional therapy with CBC. Anxiety, depression and PTSD are closely related conditions, and CBC is showing promise with many psychological conditions as of this writing.

Final Words on Hemp Oil and Anxiety

Hemp Oil Anxiety and The Entourage EffectThe studies are very clear, and point to CBD as the primary cannabinoid that may help with anxiety.

As we noted, anxiety, panic attacks, depression, OCD and PTSD are very closely related conditions. Although CBD has been indicated in the treatment of anxiety, CBC has also shown promise in the treatment of depression as well as overall brain and neurological health.

Given The Entourage Effect[10,11], where the presence of all cannabinoids, terpenes and flavonoids appear to have a synergistic effect, it would seem to be ‘best practice’ to treat with a full-spectrum hemp oil in order to receive the full health effects of CBD, CBC or any of the other critical cannabinoids.

It should also be noted that hemp oil manufacturers are beginning to create CBD and CBC oil products in a 1:1 ratio given how closely these two cannabinoids treat anxiety, depression and overall brain health.

References
1. Crippa, J.A., Derenusson, G.N., Ferrari, T.B., Wichert-Ana, L., Duran, F.L., Martin-Santos, R., Simoes, M.V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., Santos Filho, A., Freitas-Ferrari, M.C., McGuire, P.K., Zuardi, A.W., Busatto, G.F., and Hallak, J.E. (2011, January). Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Journal of Psychopharmacology, 25(1), 121-30.
2. Bergamaschi, M.M., Queiroz, R.H., Chagas, M.H., de Oliveira, D.C., De Martinis, B.S., Kapczinski, F., Quevedo, J., Roesler, R., Schroder, N., Nardi, A.E., Martin-Santos, R., Hallak, J.E., Zuardo, A.W., and Crippa, J.A. (2011, May). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology, 36(6), 1219-26.
3. Haj-Dahmane S, Shen RY. (2011, September) Modulation of the serotonin system by endocannabinoid signaling. Neuropharmacology, 61(3):414-20.
4. Simone Tambaro, Marco Bortolato (2012, April) Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives. Recent Patents on CNS Drug Discovery, 7(1): 25–40.
5. Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015, Oct). Cannabidiol as a potential treatment for anxiety disorders [Abstract]. Neurotherapeutics, 12(4), 825-836.
6. Shannon, S., Opila-Lehman, J. (2016, October). Effectiveness of cannabidiol oil for pediatric anxiety and insomnia as part of posttraumatic stress disorder: A case report. The Permanente Journal, 20(4), 108-111.
7. Rafael M. Bitencourt and Reinaldo N. Takahashi, (2018, July) Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials. Frontiers in Neuroscience, 12: 502.
8. El-Alfy, A.T., Ivey, K., Robinson, K., Ahmed, S., Radwan, M., Slade, D., Khan, I., ElSohly, M., and Ross, S. (2010, June). Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacology, Biochemistry, and Behavior, 95(4), 434-42.
9. Shinjyo, N., and Di Marzo, V. (2013, November). The effect of cannabichromene on adult neural stem/progenitor cells. Neurochemistry International, 63(5), 432-437.
10. Ben-Shabat S, Fride E, Sheskin T, Tamiri T, Rhee MH, Vogel Z, Bisogno T, De Petrocellis L, Di Marzo V, Mechoulam R (1998, July) An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol, 17;353(1):23-31.
11. Ethan B Russo (2011 August) Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7): 1344–1364.
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