Hemp Oil for Nausea

Hemp Oil for Nausea

Hemp Oil For NauseaYou may have heard people extolling the virtues of hemp oil for nausea. The truth is that medical studies indicate a strong potential for treating nausea with hemp oil. Now let’s take a look at the facts because the specifics matter.

We will identify the major studies, the evidence and which cannabinoids seem to be the big players in mitigating the effects of nausea and vomiting.

If you have been experiencing nausea for more than a day, then you should see a medical professional as this may be a sign of a more serious condition.

Before we get started, it is important to identify the various causes of nausea. Some are worse than others, and it is reported that nausea resulting from chemotherapy is among the worst.

Causes of Nausea

There are many condition, disorders and diseases that can cause nausea, and even vomiting. Let’s take a look at some of the primary causes:

• Chemotherapy
• Migraine
• Morning sickness
• Motion sickness
• General anesthesia
• Stomach Flu (viral gastroenteritis)
• Rotavirus
• Intestinal obstruction
• Inner Ear Disorder (vestibular neuritis)
• Gastroparesis (inability to fully empty stomach)

Here is just a sampling of the many other conditions that can cause nausea or vomiting:

• Acute liver failure
• Alcohol use disorder
• Anaphylaxis
• Crohn’s disease
• Depression
• Ear infection (middle ear)
• Gallstones
• Gastroesophageal reflux disease (GERD)
• Generalized anxiety disorder
• Heart attack
• Heart failure
• Irritable bowel syndrome
• Medications
• Meniere’s disease
• Meningitis
• Radiation therapy
• Severe pain

One interesting fact is that serotonin stimulates the part of the brain that causes nausea, and helps control bowel movements. In fact, serotonin levels increase when you have eaten disagreeable food, with the serotonin acting to cause diarrhea.

The reason this is important is because nausea can be counteracted by compounds that bind to serotonin receptors. We will learn below that certain cannabinoids in hemp oil can do exactly this.

Hemp Oil, Cannabinoids and Nausea

Hemp Oil For VomitingLet’s take a look at the studies that show the most promise in treating the symptoms of nausea and vomiting:

Nausea – In a June, 2012 study, Dr. Schier[1] reviewed all studies which evaluated the effectiveness of CBD with nausea and anxiety in mice.

The study found that CBD was highly effective in both mitigating anxiety and nausea. In the study they summarized by stating, “CBD exhibited an anti-anxiety and antidepressant effects in animal models”, and “the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor (serotonin receptor)”.

Nausea – In an August, 2011 study, Dr. Parker[2] isolated specific cannabinoids that help mitigate nausea, including Δ(9) -THC, CBD, HU-210, and fatty acid amide hydrolase (FAAH) inhibitor, URB-597.

Dr. Parker summarized “Preclinical research indicates that cannabinioids, including CBD, may be effective clinically for treating both nausea and vomiting produced by chemotherapy or other therapeutic treatments”.

Nausea and Vomiting – In a March, 2013 study, Dr. Bolognini[3] was specifically evaluating whether CBDa (cannabidiolic acid) could reduce nausea and vomiting.

The study found “Compared with CBD (cannabidiol), CBDa displays significantly greater potency at inhibiting vomiting”. They also stated “CBDa shows promise as a treatment for nausea and vomiting, including anticipatory nausea for which no specific therapy is currently available”.

Nausea and Vomiting – In an April, 2012 study, Dr. Rock[4] was testing the effectiveness of CBD by controlling the ability to induce nausea using endocannabinoid receptors.

The study essentially validated that CBD works to mitigate nausea and vomiting by stating, “These results suggest that CBD produced its anti-emetic/anti-nausea effects by indirect activation of the somatodendritic 5-HT(1A) autoreceptors in the DRN”.

Nausea and Vomiting – In a June, 2011 study, Dr. Rock[5] tested to see if CBG (cannabigerol) had any positive or negative interactions with CBD in the treatment of nausea and vomiting.

The study found that CBG interacted with CBD negatively, undermining the performance of CBD in treating nausea and vomiting, “Interactions between moderate doses of CBG and CBD may oppose one another at the 5-HT(1A) receptor in the regulation of nausea and vomiting.”.

Nausea and Vomiting – In an April, 2002 study, Dr. Parker[6] ran a specific test on rats to understand the effectiveness of CBD in preventing nausea or vomiting when introduced to lithium chloride. This would essentially serve as a proxy for understanding the nausea associated with chemotherapy.

The results were very positive, where they stated, “These results suggest that cannabinoids without psychoactive side-effects may have therapeutic value in the treatment of chemotherapy-induced nausea”.

Nausea and Vomiting – In a November, 2010 study, Dr. Duran[7] tested to see if cannabis could help chemotherapy-induced nausea and vomiting (CINV) patients.

The results were very positive, stating “Compared with placebo, cannabis based medicine (CBM) added to standard antiemetic (a drug that is effective against vomiting and nausea) therapy was well tolerated and provided better protection against delayed chemotherapy-induced nausea and vomiting (CINV). These results should be confirmed in a phase III clinical trial”.

Nausea – In a September, 2016 study, Dr. Rock[7] tested the effectiveness of combining Δ(9)-THC and cannabidiolic acid (CBDa) for symptoms of nausea and anticipatory nausea.

The results of the study were stellar, with the study concluding “Oral administration of subthreshold doses of THC and CBDA may be an effective new treatment for acute nausea and anticipatory nausea and appetite enhancement in chemotherapy patients”.

The Evidence of Hemp Oil and Nausea

Hemp Oil Helps NauseaThere have been many studies performed to understand the relationship of cannabinoids and nausea. They have found that the symptoms of nausea could be lessened by creating interaction with the CB1 and CB2 receptors – something that hemp oil does very well.

However, the studies show more specifically that CBD, CBDa and Δ(9)-THC (the cannabinoid that gets you high) are the cannabinoids of choice in treating nausea and vomiting.

The study that caught our eye, though, was the June, 2011 study by Dr. Rock that concluded that CBG might interfere with the effectiveness of CBD in mitigating nausea.

This might give some pause on whether full spectrum hemp oil could be effective with nausea – given that CBG is present. However, this particular study was testing CBD vs. CBG in equal amounts.

In nature, CBG is found in much smaller quantities in natural hemp and hemp oil (relative to CBD) – so there is a strong likelihood that these two cannabinoids would not negate each other if using full spectrum hemp oil in treating nausea.

1. Schier AR, Ribeiro NP, Silva AC, Hallak JE, Crippa JA, Nardi AE, Zuardi AW. (2012, June) Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug. Rev Brazilian Journal of Psychiatry, 34(Supl1): S104-S117.
2. Parker LA, Rock EM, Limebeer CL. (2011, August) Regulation of Nausea and Vomiting by Cannabinoids. British Journal of Pharmacology, 163(7):1411-22.
3. Bolognini D, Rock EM, Cluny NL, Cascio MG, Limebeer CL, Duncan M, Stott CG, Javid FA, Parker LA, Pertwee RG. (2013, March) Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. British Journal of Pharmacology, 168(6):1456-70.
4. Rock EM, Bolognini D, Limebeer CL, Cascio MG, Anavi-Goffer S, Fletcher PJ, Mechoulam R, Pertwee RG, Parker LA. (2012, April) Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. British Journal of Pharmacology, 165(8):2620-34.
5. Rock EM, Goodwin JM, Limebeer CL, Breuer A, Pertwee RG, Mechoulam R, Parker LA. (2011, June) Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. Psychopharmacology, 215(3):505-12.
6. Parker LA, Mechoulam R, Schlievert C. (2002, April) CBD: its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats. Neuroreport, 13(5):567-70.
7. Duran M, Pérez E, Abanades S, Vidal X, Saura C, Majem M, Arriola E, Rabanal M, Pastor A, Farré M, Rams N, Laporte JR, Capellà D. (2010, November) Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. British Journal of Clinical Pharmacology, 70(5):656-63.
8. Rock EM, Connolly C, Limebeer CL, Parker LA. (2016, September) Effect of combined oral doses of THC & CBDA on acute and anticipatory nausea in rat models. Psychopharmacology, 233(18):3353-60.
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